To create a graphical interface (GUI) in Python you need to make use of a library or module. There are at least three widely used modules for creating GUIs with Python:
While you can create a graphical user interface (GUI) with any of these modules, they do not have the same features.
Tk provides basic widgets such as a button, menu, text and label. It is very limited compared to QT4 and WxPython but it is also the oldest module. It runs on most versions of Mac OS, Linux and Windows.
QT4 and QT5 are developed by the Qt company. Graphical applications made with QT4 or QT5 run on Windows, Linux/X11 and Mac OS X. It has tons of widgets including tabs, buttons, item views, table views, progressbars, input fields, calendar views and many more. Compared to Tk it has a lot more widgets available.
WxPython is a module that creates a native GUI look regardless of the operating system used. On Windows it will look as windows application while on Mac OS it will look as a Mac application. This can be a clear advantage compared to QT4 or Tk, depending on your purpose. WxWidgets has many widgets available such as buttons, menu, text but also more advanced widgets as a htmlview or tree control.